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La Grande Back Pain Related to Inflammation Reduced with Melatonin

Inflammation. Disc Degeneration. There is a connection. Inflammation acts as the body’s response system to damaging stimuli (injury, pathogens, metabolic stress – a disc herniation compressing a nerve!) as it attempts to restore itself to normal before the harm was done. Paulette Hugulet, DC, LLC is always amazed at what the body can do! Paulette Hugulet, DC, LLC sees its La Grande chiropractic care as a partner of the body’s system in healing especially when spine pain is an issue. Chiropractic care utilizes many tools like spinal manipulation, exercise, and nutrition to help the body. Melatonin is one nutritional tool that is proving value in its ability to interrupt the inflammatory process related disc herniation that results in back pain, neck pain and other spine related pain.

DISC DEGENERATION AND INFLAMMATION AND 'AUTOPHAGY'

Inflammatory markers interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) are related to intervertebral disc degeneration. (1) IL-1 β in fact promotes itself, its own expression, by upregulating NLRP3 inflammasome activation. (2) The body regulates itself down to its cellular level via autophagy, the natural process via which the body’s cells clear out damaged (ie, by inflammation) or unneeded parts. In a new study, melatonin enhanced autophagy and reduced the degradation of the disc’s extracellular matrix (technically indicated by a decline in marker LC3B, autophagasomes and autolysosomes and inhibition of the NF-kB signaling pathway). The end conclusion was that melatonin prevents intervertebral disc degeneration by stimulating autophagy. (3) Wow. Paulette Hugulet, DC, LLC is inspired by this research to see just how well melatonin can perform for La Grande back pain related to disc degeneration.

MELATONIN AND ITS HEALING WAYS FOR THE DISC

Disc degeneration is quite a common malady seen at Paulette Hugulet, DC, LLC making positive news like this quite exciting. A recent study described that melatonin could modify the extracellular matrix of the disc remodeling process started by IL-1 β. Further, melatonin decreased the inflammatory cell collection and decreased the release of associated inflammatory markers IL-1β, IL-6, and TNF-α. With this new finding that melatonin disrupted the IL-1B feedback loop, researchers proposed that melatonin may contribute to the healing process of intervertebral discs after damage has already been done. (1) Paulette Hugulet, DC, LLC continues following the new research regarding the role inflammation has in La Grande disc degeneration and melatonin’s role in tackling it.

INFLAMMATION AND MELATONIN

The importance of melatonin in helping to slow or stop painful conditions due to inflammation is increasing. The description of melatonin as a multitasking molecule affecting mood, immunity, and energy among other things is quite suitable. It is also anti-oxidant, anti-aging, and anti-inflammatory, specifically by blocking the activation of inflammasomes (4) Melatonin’s formal chemical name is as about as long as its list of tasks: N-acetyl-5-methoxytryptamine. The pineal gland secretes melatonin naturally. Melatonin influences the body’s aging, anti-inflammatory, anti-apoptosis (cell death), and autophagy (cell-cleanout) processes. (1) Melatonin’s specific influence on inflammation and disc degeneration is most attention-getting to Paulette Hugulet, DC, LLC and our La Grande back pain patients.

CONTACT Paulette Hugulet, DC, LLC

Listen to this PODCAST with Dr. Hrefna Sylvia based in Iceland where back pain isn’t much different from any other country on The Back Doctors Podcast with Dr. Michael Johnson as she describes how The Cox® Technic System of Spinal Pain Management handles disc degeneration for relief of chronic low back pain in her patient.

Schedule your La Grande chiropractic appointment with Paulette Hugulet, DC, LLC now. We can discuss the role inflammation plays in your back pain experience and how melatonin may help with the related disc degeneration.

 
Paulette Hugulet, DC, LLC presents new findings that melatonin interrupts the inflammatory process in disc degeneration that causes back pain. 
 
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